Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Formin Binding Protein 1 (FNBP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Formin Binding Protein 1 (FNBP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Formin Binding Protein 1 (FNBP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Formin Binding Protein 1 (FNBP1) in Tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Formin Binding Protein 1 (FNBP1) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Description: Recombinant Human Formin Binding Protein 1 expressed in: E.coli

Description: A sandwich ELISA kit for detection of Formin Binding Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Formin-binding protein 1 (FNBP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Formin-binding protein 1 (FNBP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Formin-binding protein 1 (FNBP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1)

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Formin Binding Protein 1 (FNBP1). This antibody is labeled with APC-Cy7.

Description: Recombinant protein for human Formin-binding protein 1-like

Description: Description of target: The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.056 ng/mL

Description: Description of target: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.By similarity5 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.10"A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis."_x005F_x005F_x000D_Kamioka Y., Fukuhara S., Sawa H., Nagashima K., Masuda M., Matsuda M., Mochizuki N._x005F_x005F_x000D_J. Biol. Chem. 279:40091-40099(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH DNM1; DNM2 AND DNM3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PRO-602.Ref.12"Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins."_x005F_x005F_x000D_Itoh T., Erdmann K.S., Roux A., Habermann B., Werner H., De Camilli P._x005F_x005F_x000D_Dev. Cell 9:791-804(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH DNM1 AND WASL, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-7.Ref.13"Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL."_x005F_x005F_x000D_Qian J., Chen W., Lettau M., Podda G., Zoernig M., Kabelitz D., Janssen O._x005F_x005F_x000D_Cell. Signal. 18:1327-1337(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH FASLG, SUBCELLULAR LOCATION.Ref.15"Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis."_x005F_x005F_x000D_Tsujita K., Suetsugu S., Sasaki N., Furutani M., Oikawa T., Takenawa T._x005F_x005F_x000D_J. Cell Biol. 172:269-279(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH DNM2 AND WASL, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-33; ARG-35; 51-LYS-LYS-52 AND 113-ARG-LYS-114.Ref.27"Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis."_x005F_x005F_x000D_Shimada A., Niwa H., Tsujita K., Suetsugu S., Nitta K., Hanawa-Suetsugu K., Akasaka R., Nishino Y., Toyama M., Chen L., Liu Z.-J., Wang B.C., Yamamoto M., Terada T., Miyazawa A., Tanaka A., Sugano S., Shirouzu M. , Nagayama K., Takenawa T., Yokoyama S._x005F_x005F_x000D_Cell 129:761-772(2007) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 1-300, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DOMAIN F-BAR, COILED-COIL DOMAIN, MUTAGENESIS OF LYS-33; THR-165; LYS-166; ASP-168 AND PRO-210. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.056 ng/mL