Human brain gene expression atlas project

Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs

ZFP57 is required to keep up the germline-marked differential methylation at imprinting management areas (ICRs) in mouse embryonic stem cells (ESCs). Although DNA methylation has a key role in genomic imprinting, a number of imprinted genes are managed by completely different mechanisms, and a complete research of the relationship between DMR methylation and imprinted gene expression is missing. To tackle the latter subject, we differentiated...