Tropilaelaps mercedesae is without doubt one of the most problematic honey bee parasites and has change into extra threatening to the beekeeping business. Tropilaelaps can simply parasitize immature honey bees (larvae and pupae) and have each deadly and sublethal results on the person employee bees. Our examine for the primary time experimentally assessed the consequences of T. mercedesae on olfactory studying, flight means, homing means in addition to transcriptional changes in parasitized grownup honey bees.
T. mercedesae infestation had adverse impacts on olfactory related perform, flight means, and homing charge. The quantity of the mushroom physique considerably elevated in infested honey bees, which can be correlated to the decrease sucrose responsiveness in addition to decrease studying means in the infested bees.
The gene expression concerned in immune programs and carbohydrate transport and metabolism have been considerably completely different between infested bees and non-infested bees. Moreover, genes perform in cell adhesion play an important function in olfactory sensory in honey bees. Our findings present a complete understanding of European honey bees in response to T. mercedesae infestation, and might be used to additional examine the complicated molecular mechanisms in honey bees beneath parasitic stress.
Loss of inner-envelope Ok+/H+ exchangers impairs plastid rRNA maturation and gene expression
The inner-envelope Ok+ EFFLUX ANTIPORTERS (KEA) 1 and 2 are essential for chloroplast improvement, ion homeostasis, and photosynthesis. However, the mechanisms by which changes in ion flux throughout the envelope have an effect on organelle biogenesis remained elusive. Chloroplast improvement requires intricate coordination between the nuclear genome and the plastome. Many mutants compromised in plastid gene expression (PGE) show a virescent phenotype, i.e. delayed greening.
The phenotypic look of Arabidopsis thaliana kea1 kea2 double mutants fulfills this criterion, but a hyperlink to PGE has not been explored. Here, we present {that a} simultaneous lack of KEA1 and KEA2 outcomes in maturation defects of the plastid ribosomal RNAs. This could also be brought on by secondary construction changes of rRNA transcripts and concomitant lowered binding of RNA-processing proteins, which we documented in the presence of skewed ion homeostasis in kea1 kea2.
Consequently, protein synthesis and steady-state ranges of plastome-encoded proteins stay low in mutants. Disturbance in PGE and different indicators of plastid malfunction activate GUN1-dependent retrograde signaling in kea1 kea2, ensuing in a dramatic downregulation of GOLDEN2-LIKE transcription components to halt expression of photosynthesis-associated nuclear-encoded genes (PhANGs). PhANG suppression delays the event of absolutely photosynthesizing kea1 kea2 chloroplasts, in all probability to keep away from progressing photo-oxidative harm. Overall, our outcomes reveal that KEA1/KEA2 perform impacts plastid improvement by way of results on RNA-metabolism and PGE.
Effects of Tris (2-chloroethyl) phosphate (TCEP) on survival, development, histological changes and gene expressions in juvenile yellow catfish Pelteobagrus fulvidraco
Tris (2-chloroethyl) phosphate (TCEP) is an rising aquatic environmental pollutant. In the current examine, juvenile yellow catfish (Pelteobagrus fulvidraco) have been uncovered to environmentally related concentrations of TCEP for 30 days. The outcomes confirmed that TCEP publicity decreased the survival charge (100 μg/L), physique weight (10 and 100 μg/L) and particular development charge (10 and 100 μg/L) of juvenile yellow catfish.
Exposure to TCEP resulted in pronounced damages of gill buildings. Gene transcription evaluation confirmed that the antioxidant capability of the liver and gills was affected; CYP1A1 may contribute to section I metabolism of TCEP in the liver slightly than CYP1B1; TCEP stress may improve the demand of ion transport in fish gill; TCEP may stimulate the immune response and may induce apoptosis by way of a p53-Bax pathway and caspase-dependent pathway in gills. Collectively, these findings present new insights into the poisonous results of TCEP on fish.
Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes
We beforehand discovered that DNA methyltransferase 3a (DNMT3a) performs an essential function in regulating embryonic cardiomyocyte gene expression, morphology, and perform. In this examine, we investigated the function of essentially the most plentiful DNMT in mammalian cells, DNMT1, in these processes. It is understood that DNMT1 is crucial for embryonic improvement, throughout which it’s concerned in regulating cardiomyocyte DNA methylation and gene expression.
We used siRNA to knockdown DNMT1 expression in major cultures of mouse embryonic cardiomyocytes. Immunofluorescence staining and multi-electrode array have been respectively utilized to judge cardiomyocyte development and electrophysiology. RNA-sequencing (RNA-Seq) and multiplex bisulfite sequencing have been respectively carried out to look at gene expression and promoter methylation. At 72 hours post-transfection, discount of DNMT1 expression decreased the quantity and elevated the scale of embryonic cardiomyocytes.
Beat frequency and the amplitude of area motion potentials have been decreased by DNMT1 siRNA. RNA-Seq evaluation recognized 801 upregulated genes and 494 downregulated genes in the DNMT1 knock-down cells when in comparison with controls. Pathway evaluation of the differentially expressed genes revealed pathways that have been related to cell demise and survival, cell morphology, cardiac perform, and cardiac illness. Alternative splicing evaluation recognized 929 differentially expressed exons, together with 583 up-regulated exons and 308 down-regulated exons.
BMP3 Over-expression Lysate Product |
GWB-8982EA |
GenWay Biotech |
0.1 mg |
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BMP1 Over-expression Lysate Product |
GWB-B9DBA3 |
GenWay Biotech |
0.1 mg |
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BMP7 Over-expression Lysate Product |
GWB-CDBF05 |
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0.1 mg |
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BMP8B Over-expression Lysate Product |
GWB-FCC50C |
GenWay Biotech |
0.1 mg |
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BMP2K Over-expression Lysate Product |
GWB-D01E56 |
GenWay Biotech |
0.1 mg |
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BMPR2 Over-expression Lysate Product |
GWB-CB3579 |
GenWay Biotech |
0.1 mg |
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h BMP2 Expression, Concentrated Lentivirus |
LVP481-PBS |
GenTarget |
1x10^8 IFU/ml x 200ul |
EUR 455 |
Description: Pre-made express human target: BMP2 gene, carrying RFP-Blasticidin dual selection. |
NEU3 Over-expression Lysate |
GWB-DL2468 |
GenWay Biotech |
0.1 mg |
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Protein expression |
CRO-4-Ind |
Jotbody |
each |
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RFP expression Adenovirus, in vivo ready |
AVP001-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made RFP expression adenovirus, provided in PBS solution. |
CFP expression Adenovirus, in vivo ready |
AVP002-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made CFP expression adenovirus, provided in PBS solution. |
GFP expression Adenovirus, in vivo ready |
AVP011-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made GFP expression adenovirus, provided in PBS solution. |
YFP expression Adenovirus, in vivo ready |
AVP012-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made YFP expression adenovirus, provided in PBS solution. |
BFP expression Adenovirus, in vivo ready |
AVP017-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made BFP expression adenovirus, provided in PBS solution. |
293 Expression MAX-1 |
EXP-711-11 |
ACROBIOSYSTEMS |
1ml |
EUR 214 |
|
Description: 293 Expression MAX-1 is expressed from - -. |
PEROXIDE BLOCKING REAGENT Reagent |
GWB-Q00308 |
GenWay Biotech |
50 ml |
Ask for price |
CNGA2 Expression vector |
60642 |
BPS Bioscience |
20 µg |
EUR 900 |
Description: The CNGA2 expression vector is designed to express human cyclic nucleotide-gated cation channel 2 (CNGA2) in mammalian cells. |
LEXSYcon2.1 Expression Kit |
EGE-1310ble |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
LEXSYcon2.1 Expression Kit |
EGE-1310bsd |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
LEXSYcon2.1 Expression Kit |
EGE-1310hyg |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
LEXSYcon2.1 Expression Kit |
EGE-1310neo |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
LEXSYcon2.1 Expression Kit |
EGE-1310pac |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
LEXSYcon2.1 Expression Kit |
EGE-1310sat |
Jena Bioscience GmbH |
1Kit |
EUR 1296.1 |
Description: for constitutive cytosolic or secretory protein expression |
h OCT4 expression Adenovirus, in vivo ready |
AVP013-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in PBS solution for in vivo application. |
h SOX2 expression Adenovirus, in vivo ready |
AVP014-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in PBS solution for in vivo application. |
Blunt E1 Expression Kit |
abx098098-10rxns |
Abbexa |
10 rxns |
EUR 560.4 |
|
Blunt E2 Expression Kit |
abx098873-10rxns |
Abbexa |
10 rxns |
EUR 560.4 |
|
Blunt E1 Expression Kit |
abx098098-100l |
Abbexa |
100 µl |
EUR 712.5 |
Blunt E1 Expression Kit |
abx098098-1ml |
Abbexa |
1 ml |
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Blunt E1 Expression Kit |
abx098098-200l |
Abbexa |
200 µl |
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Blunt E2 Expression Kit |
abx098873-100l |
Abbexa |
100 µl |
EUR 712.5 |
Blunt E2 Expression Kit |
abx098873-1ml |
Abbexa |
1 ml |
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Blunt E2 Expression Kit |
abx098873-200l |
Abbexa |
200 µl |
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RFP expression Adenovirus |
AVP001 |
GenTarget |
1x109 IFU/ml x 200ul |
EUR 418.8 |
Description: pre-made RFP expression adenovirus, provided in DMEM medium. |
CFP expression Adenovirus |
AVP002 |
GenTarget |
1x109 IFU/ml x 200ul |
EUR 418.8 |
Description: pre-made CFP expression adenovirus, provided in DMEM medium. |
GFP expression Adenovirus |
AVP011 |
GenTarget |
1x109 IFU/ml x 200ul |
EUR 418.8 |
Description: pre-made GFP expression adenovirus, provided in DMEM medium. |
YFP expression Adenovirus |
AVP012 |
GenTarget |
1x109 IFU/ml x 200ul |
EUR 418.8 |
Description: pre-made YFP expression adenovirus, provided in DMEM medium. |
BFP expression Adenovirus |
AVP017 |
GenTarget |
1x109 IFU/ml x 200ul |
EUR 418.8 |
Description: pre-made BFP expression adenovirus, provided in DMEM medium. |
RPL21_17_477 Over-expression Lysate Product |
GWB-8BD971 |
GenWay Biotech |
0.1 mg |
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h LIN28 expression Adenovirus, in vivo ready |
AVP015-PBS |
GenTarget |
1x1011 IFU/ml x 50ul |
EUR 852 |
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in PBS solution for in vivo application. |
LEXSinduce3 Expression Kit |
EGE-1410ble |
Jena Bioscience GmbH |
1Kit |
EUR 3037.6 |
Description: for inducible cytosolic or secretory protein expression |
LEXSinduce3 Expression Kit |
EGE-1410blecherry |
Jena Bioscience GmbH |
1Kit |
EUR 3037.6 |
Description: for inducible cytosolic or secretory protein expression |
LEXSinduce3 Expression Kit |
EGE-1410neo |
Jena Bioscience GmbH |
1Kit |
EUR 3037.6 |
Description: for inducible cytosolic or secretory protein expression |
LEXSinduce4 Expression Kit |
EGE-1420blecherry |
Jena Bioscience GmbH |
1Kit |
EUR 3037.6 |
Description: for inducible cytosolic or secretory protein expression |
F8 Over-expression Lysate Product |
GWB-4223CC |
GenWay Biotech |
0.1 mg |
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AR Over-expression Lysate Product |
GWB-524326 |
GenWay Biotech |
0.1 mg |
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MB Over-expression Lysate Product |
GWB-543EE8 |
GenWay Biotech |
0.1 mg |
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C5 Over-expression Lysate Product |
GWB-611C50 |
GenWay Biotech |
0.1 mg |
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F7 Over-expression Lysate Product |
GWB-2B9655 |
GenWay Biotech |
0.1 mg |
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HP Over-expression Lysate Product |
GWB-19D90B |
GenWay Biotech |
0.1 mg |
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C9 Over-expression Lysate Product |
GWB-A98C50 |
GenWay Biotech |
0.1 mg |
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GK Over-expression Lysate Product |
GWB-ABEC99 |
GenWay Biotech |
0.1 mg |
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C6 Over-expression Lysate Product |
GWB-4CD0B5 |
GenWay Biotech |
0.1 mg |
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T Over-expression Lysate Product |
GWB-4D17A7 |
GenWay Biotech |
0.1 mg |
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C2 Over-expression Lysate Product |
GWB-69AF56 |
GenWay Biotech |
0.1 mg |
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C7 Over-expression Lysate Product |
GWB-6F310B |
GenWay Biotech |
0.1 mg |
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GC Over-expression Lysate Product |
GWB-6FD425 |
GenWay Biotech |
0.1 mg |
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F2 Over-expression Lysate Product |
GWB-74B4A0 |
GenWay Biotech |
0.1 mg |
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GK Over-expression Lysate Product |
GWB-799C20 |
GenWay Biotech |
0.1 mg |
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F9 Over-expression Lysate Product |
GWB-7A1142 |
GenWay Biotech |
0.1 mg |
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TF Over-expression Lysate Product |
GWB-FDE7E0 |
GenWay Biotech |
0.1 mg |
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FH Over-expression Lysate Product |
GWB-B00EEC |
GenWay Biotech |
0.1 mg |
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KL Over-expression Lysate Product |
GWB-EF6FA2 |
GenWay Biotech |
0.1 mg |
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MB Over-expression Lysate Product |
GWB-DDB100 |
GenWay Biotech |
0.1 mg |
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XG Over-expression Lysate Product |
GWB-C19FF5 |
GenWay Biotech |
0.1 mg |
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PC Over-expression Lysate Product |
GWB-C40C56 |
GenWay Biotech |
0.1 mg |
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Rac1 Expression Vector Set |
STA-454 |
Cell Biolabs |
1 kit |
EUR 1765.2 |
Description: Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and G12V constitutively active mutant. |
RhoA Expression Vector Set |
STA-456 |
Cell Biolabs |
1 kit |
EUR 1765.2 |
Description: RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and G14V constitutively active mutant. |
CRX Over-expression Lysate Product |
GWB-372B50 |
GenWay Biotech |
0.1 mg |
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FST Over-expression Lysate Product |
GWB-3758FE |
GenWay Biotech |
0.1 mg |
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PNN Over-expression Lysate Product |
GWB-379ABB |
GenWay Biotech |
0.1 mg |
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CRK Over-expression Lysate Product |
GWB-37B7E4 |
GenWay Biotech |
0.1 mg |
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B2M Over-expression Lysate Product |
GWB-39B4E3 |
GenWay Biotech |
0.1 mg |
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NGB Over-expression Lysate Product |
GWB-39F54D |
GenWay Biotech |
0.1 mg |
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KIN Over-expression Lysate Product |
GWB-3ABEBE |
GenWay Biotech |
0.1 mg |
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OXT Over-expression Lysate Product |
GWB-3B1FD3 |
GenWay Biotech |
0.1 mg |
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PXK Over-expression Lysate Product |
GWB-3C8EA1 |
GenWay Biotech |
0.1 mg |
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ALB Over-expression Lysate Product |
GWB-3E03B0 |
GenWay Biotech |
0.1 mg |
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IL9 Over-expression Lysate Product |
GWB-3E3A84 |
GenWay Biotech |
0.1 mg |
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HLA Over-expression Lysate Product |
GWB-3E6FB0 |
GenWay Biotech |
0.1 mg |
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SPR Over-expression Lysate Product |
GWB-3FACD1 |
GenWay Biotech |
0.1 mg |
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SPN Over-expression Lysate Product |
GWB-404D95 |
GenWay Biotech |
0.1 mg |
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AIP Over-expression Lysate Product |
GWB-40DF2C |
GenWay Biotech |
0.1 mg |
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CSK Over-expression Lysate Product |
GWB-415B1A |
GenWay Biotech |
0.1 mg |
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WT1 Over-expression Lysate Product |
GWB-41C1E8 |
GenWay Biotech |
0.1 mg |
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C8B Over-expression Lysate Product |
GWB-41E9AB |
GenWay Biotech |
0.1 mg |
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HDC Over-expression Lysate Product |
GWB-4302B9 |
GenWay Biotech |
0.1 mg |
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TNF Over-expression Lysate Product |
GWB-448BBB |
GenWay Biotech |
0.1 mg |
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PNP Over-expression Lysate Product |
GWB-4538EC |
GenWay Biotech |
0.1 mg |
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MUT Over-expression Lysate Product |
GWB-455C37 |
GenWay Biotech |
0.1 mg |
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CFP Over-expression Lysate Product |
GWB-4575E9 |
GenWay Biotech |
0.1 mg |
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HPN Over-expression Lysate Product |
GWB-4602DE |
GenWay Biotech |
0.1 mg |
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C1D Over-expression Lysate Product |
GWB-461FBD |
GenWay Biotech |
0.1 mg |
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PIP Over-expression Lysate Product |
GWB-4782A0 |
GenWay Biotech |
0.1 mg |
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SF1 Over-expression Lysate Product |
GWB-47A9D3 |
GenWay Biotech |
0.1 mg |
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DDO Over-expression Lysate Product |
GWB-481A81 |
GenWay Biotech |
0.1 mg |
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LYZ Over-expression Lysate Product |
GWB-4830E7 |
GenWay Biotech |
0.1 mg |
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PAM Over-expression Lysate Product |
GWB-48AFF2 |
GenWay Biotech |
0.1 mg |
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DCN Over-expression Lysate Product |
GWB-4AB343 |
GenWay Biotech |
0.1 mg |
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MVD Over-expression Lysate Product |
GWB-4B1DAE |
GenWay Biotech |
0.1 mg |
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CPM Over-expression Lysate Product |
GWB-4B1F3E |
GenWay Biotech |
0.1 mg |
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REN Over-expression Lysate Product |
GWB-4B825B |
GenWay Biotech |
0.1 mg |
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HRK Over-expression Lysate Product |
GWB-4BB955 |
GenWay Biotech |
0.1 mg |
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SHD Over-expression Lysate Product |
GWB-4BFEE6 |
GenWay Biotech |
0.1 mg |
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GH1 Over-expression Lysate Product |
GWB-4F3DD0 |
GenWay Biotech |
0.1 mg |
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IVD Over-expression Lysate Product |
GWB-4F555F |
GenWay Biotech |
0.1 mg |
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SLA Over-expression Lysate Product |
GWB-4F6FFE |
GenWay Biotech |
0.1 mg |
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AK4 Over-expression Lysate Product |
GWB-4FADC0 |
GenWay Biotech |
0.1 mg |
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BRE Over-expression Lysate Product |
GWB-4FC6EC |
GenWay Biotech |
0.1 mg |
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MOS Over-expression Lysate Product |
GWB-503237 |
GenWay Biotech |
0.1 mg |
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ERF Over-expression Lysate Product |
GWB-5242BB |
GenWay Biotech |
0.1 mg |
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HFE Over-expression Lysate Product |
GWB-5243B9 |
GenWay Biotech |
0.1 mg |
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TEK Over-expression Lysate Product |
GWB-533C4C |
GenWay Biotech |
0.1 mg |
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MIA Over-expression Lysate Product |
GWB-534100 |
GenWay Biotech |
0.1 mg |
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IDE Over-expression Lysate Product |
GWB-5367D7 |
GenWay Biotech |
0.1 mg |
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AFP Over-expression Lysate Product |
GWB-536D51 |
GenWay Biotech |
0.1 mg |
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RDX Over-expression Lysate Product |
GWB-53CF80 |
GenWay Biotech |
0.1 mg |
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ILK Over-expression Lysate Product |
GWB-54E227 |
GenWay Biotech |
0.1 mg |
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SFN Over-expression Lysate Product |
GWB-55C5F7 |
GenWay Biotech |
0.1 mg |
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BPI Over-expression Lysate Product |
GWB-55FF0C |
GenWay Biotech |
0.1 mg |
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MAX Over-expression Lysate Product |
GWB-56E43C |
GenWay Biotech |
0.1 mg |
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TAZ Over-expression Lysate Product |
GWB-572853 |
GenWay Biotech |
0.1 mg |
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MLN Over-expression Lysate Product |
GWB-576AA3 |
GenWay Biotech |
0.1 mg |
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CA2 Over-expression Lysate Product |
GWB-578B82 |
GenWay Biotech |
0.1 mg |
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GIP Over-expression Lysate Product |
GWB-57B640 |
GenWay Biotech |
0.1 mg |
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MKX Over-expression Lysate Product |
GWB-57FD34 |
GenWay Biotech |
0.1 mg |
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FAS Over-expression Lysate Product |
GWB-586DE6 |
GenWay Biotech |
0.1 mg |
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ADK Over-expression Lysate Product |
GWB-590E04 |
GenWay Biotech |
0.1 mg |
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CAT Over-expression Lysate Product |
GWB-59B4AF |
GenWay Biotech |
0.1 mg |
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AES Over-expression Lysate Product |
GWB-5A4211 |
GenWay Biotech |
0.1 mg |
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GRP Over-expression Lysate Product |
GWB-5A56CC |
GenWay Biotech |
0.1 mg |
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C8A Over-expression Lysate Product |
GWB-5AD920 |
GenWay Biotech |
0.1 mg |
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ME2 Over-expression Lysate Product |
GWB-5B40C3 |
GenWay Biotech |
0.1 mg |
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TTK Over-expression Lysate Product |
GWB-5B4DBF |
GenWay Biotech |
0.1 mg |
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HGF Over-expression Lysate Product |
GWB-5CC3A0 |
GenWay Biotech |
0.1 mg |
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XDH Over-expression Lysate Product |
GWB-5CD953 |
GenWay Biotech |
0.1 mg |
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DES Over-expression Lysate Product |
GWB-5E571D |
GenWay Biotech |
0.1 mg |
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LOX Over-expression Lysate Product |
GWB-5FE87A |
GenWay Biotech |
0.1 mg |
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BMX Over-expression Lysate Product |
GWB-603D44 |
GenWay Biotech |
0.1 mg |
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GAA Over-expression Lysate Product |
GWB-611DD0 |
GenWay Biotech |
0.1 mg |
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DR1 Over-expression Lysate Product |
GWB-62642D |
GenWay Biotech |
0.1 mg |
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ABR Over-expression Lysate Product |
GWB-62B984 |
GenWay Biotech |
0.1 mg |
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CA3 Over-expression Lysate Product |
GWB-62F5B6 |
GenWay Biotech |
0.1 mg |
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FUZ Over-expression Lysate Product |
GWB-635D50 |
GenWay Biotech |
0.1 mg |
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HGD Over-expression Lysate Product |
GWB-64C9ED |
GenWay Biotech |
0.1 mg |
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JTB Over-expression Lysate Product |
GWB-655583 |
GenWay Biotech |
0.1 mg |
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FAH Over-expression Lysate Product |
GWB-65575F |
GenWay Biotech |
0.1 mg |
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LPP Over-expression Lysate Product |
GWB-1EE6BD |
GenWay Biotech |
0.1 mg |
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QKI Over-expression Lysate Product |
GWB-2019C5 |
GenWay Biotech |
0.1 mg |
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HBB Over-expression Lysate Product |
GWB-2046D5 |
GenWay Biotech |
0.1 mg |
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ZAK Over-expression Lysate Product |
GWB-20AE0D |
GenWay Biotech |
0.1 mg |
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|
PF4 Over-expression Lysate Product |
GWB-212C3B |
GenWay Biotech |
0.1 mg |
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|
TFG Over-expression Lysate Product |
GWB-215F68 |
GenWay Biotech |
0.1 mg |
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|
ACE Over-expression Lysate Product |
GWB-21AE7F |
GenWay Biotech |
0.1 mg |
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|
ERH Over-expression Lysate Product |
GWB-220D0B |
GenWay Biotech |
0.1 mg |
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|
GIF Over-expression Lysate Product |
GWB-23C77E |
GenWay Biotech |
0.1 mg |
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|
PGD Over-expression Lysate Product |
GWB-242ED0 |
GenWay Biotech |
0.1 mg |
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|
GSN Over-expression Lysate Product |
GWB-2435DF |
GenWay Biotech |
0.1 mg |
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|
HLA Over-expression Lysate Product |
GWB-2494DC |
GenWay Biotech |
0.1 mg |
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|
Moreover, decreased methylation ranges have been discovered in the promoters of cardiac genes Myh6, Myh7, Myh7b, Tnnc1, Tnni3, Tnnt2, Nppa, Nppb, mef2c, mef2d, Camta2, Cdkn1A, and Cdkn1C. Of these 13 genes, 6 (Myh6, Tnnc1, Tnni3, Tnnt2, Nppa, Nppb) and 1 (Cdkn1C) had elevated or decreased gene expression, respectively. Altogether, these knowledge present that DNMT1 is essential in embryonic cardiomyocytes by regulating DNA methylation, gene expression, gene splicing, and cell perform.