Hudsen

Human brain gene expression atlas project

Tropilaelaps mercedesae parasitism changes behavior and gene expression in honey bee workers

Tropilaelaps mercedesae parasitism changes behavior and gene expression in honey bee workers
Tropilaelaps mercedesae is without doubt one of the most problematic honey bee parasites and has change into extra threatening to the beekeeping business. Tropilaelaps can simply parasitize immature honey bees (larvae and pupae) and have each deadly and sublethal results on the person employee bees. Our examine for the primary time experimentally assessed the consequences of T. mercedesae on olfactory studying, flight means, homing means in addition to transcriptional changes in parasitized grownup honey bees.
T. mercedesae infestation had adverse impacts on olfactory related perform, flight means, and homing charge. The quantity of the mushroom physique considerably elevated in infested honey bees, which can be correlated to the decrease sucrose responsiveness in addition to decrease studying means in the infested bees.
The gene expression concerned in immune programs and carbohydrate transport and metabolism have been considerably completely different between infested bees and non-infested bees. Moreover, genes perform in cell adhesion play an important function in olfactory sensory in honey bees. Our findings present a complete understanding of European honey bees in response to T. mercedesae infestation, and might be used to additional examine the complicated molecular mechanisms in honey bees beneath parasitic stress.

Loss of inner-envelope Ok+/H+ exchangers impairs plastid rRNA maturation and gene expression

The inner-envelope Ok+ EFFLUX ANTIPORTERS (KEA) 1 and 2 are essential for chloroplast improvement, ion homeostasis, and photosynthesis. However, the mechanisms by which changes in ion flux throughout the envelope have an effect on organelle biogenesis remained elusive. Chloroplast improvement requires intricate coordination between the nuclear genome and the plastome. Many mutants compromised in plastid gene expression (PGE) show a virescent phenotype, i.e. delayed greening.
The phenotypic look of Arabidopsis thaliana kea1 kea2 double mutants fulfills this criterion, but a hyperlink to PGE has not been explored. Here, we present {that a} simultaneous lack of KEA1 and KEA2 outcomes in maturation defects of the plastid ribosomal RNAs. This could also be brought on by secondary construction changes of rRNA transcripts and concomitant lowered binding of RNA-processing proteins, which we documented in the presence of skewed ion homeostasis in kea1 kea2.
Consequently, protein synthesis and steady-state ranges of plastome-encoded proteins stay low in mutants. Disturbance in PGE and different indicators of plastid malfunction activate GUN1-dependent retrograde signaling in kea1 kea2, ensuing in a dramatic downregulation of GOLDEN2-LIKE transcription components to halt expression of photosynthesis-associated nuclear-encoded genes (PhANGs). PhANG suppression delays the event of absolutely photosynthesizing kea1 kea2 chloroplasts, in all probability to keep away from progressing photo-oxidative harm. Overall, our outcomes reveal that KEA1/KEA2 perform impacts plastid improvement by way of results on RNA-metabolism and PGE.

Effects of Tris (2-chloroethyl) phosphate (TCEP) on survival, development, histological changes and gene expressions in juvenile yellow catfish Pelteobagrus fulvidraco

Tris (2-chloroethyl) phosphate (TCEP) is an rising aquatic environmental pollutant. In the current examine, juvenile yellow catfish (Pelteobagrus fulvidraco) have been uncovered to environmentally related concentrations of TCEP for 30 days. The outcomes confirmed that TCEP publicity decreased the survival charge (100 μg/L), physique weight (10 and 100 μg/L) and particular development charge (10 and 100 μg/L) of juvenile yellow catfish.
Exposure to TCEP resulted in pronounced damages of gill buildings. Gene transcription evaluation confirmed that the antioxidant capability of the liver and gills was affected; CYP1A1 may contribute to section I metabolism of TCEP in the liver slightly than CYP1B1; TCEP stress may improve the demand of ion transport in fish gill; TCEP may stimulate the immune response and may induce apoptosis by way of a p53-Bax pathway and caspase-dependent pathway in gills. Collectively, these findings present new insights into the poisonous results of TCEP on fish.

Tropilaelaps mercedesae parasitism changes behavior and gene expression in honey bee workers
Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes

We beforehand discovered that DNA methyltransferase 3a (DNMT3a) performs an essential function in regulating embryonic cardiomyocyte gene expression, morphology, and perform. In this examine, we investigated the function of essentially the most plentiful DNMT in mammalian cells, DNMT1, in these processes. It is understood that DNMT1 is crucial for embryonic improvement, throughout which it’s concerned in regulating cardiomyocyte DNA methylation and gene expression.
We used siRNA to knockdown DNMT1 expression in major cultures of mouse embryonic cardiomyocytes. Immunofluorescence staining and multi-electrode array have been respectively utilized to judge cardiomyocyte development and electrophysiology. RNA-sequencing (RNA-Seq) and multiplex bisulfite sequencing have been respectively carried out to look at gene expression and promoter methylation. At 72 hours post-transfection, discount of DNMT1 expression decreased the quantity and elevated the scale of embryonic cardiomyocytes.
Beat frequency and the amplitude of area motion potentials have been decreased by DNMT1 siRNA. RNA-Seq evaluation recognized 801 upregulated genes and 494 downregulated genes in the DNMT1 knock-down cells when in comparison with controls. Pathway evaluation of the differentially expressed genes revealed pathways that have been related to cell demise and survival, cell morphology, cardiac perform, and cardiac illness. Alternative splicing evaluation recognized 929 differentially expressed exons, together with 583 up-regulated exons and 308 down-regulated exons.

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Ch-48T 48T
EUR 454
  • Should the Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Ch-96T 96T
EUR 587
  • Should the Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-g-48T 48T
EUR 503
  • Should the Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Goat Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-g-96T 96T
EUR 654
  • Should the Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Goat Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Hu-48T 48T
EUR 425
  • Should the Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Hu-96T 96T
EUR 548
  • Should the Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Mu-48T 48T
EUR 435
  • Should the Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Mu-96T 96T
EUR 561
  • Should the Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-p-48T 48T
EUR 493
  • Should the Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-p-96T 96T
EUR 641
  • Should the Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Ra-48T 48T
EUR 454
  • Should the Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Ra-96T 96T
EUR 587
  • Should the Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Rb-48T 48T
EUR 454
  • Should the Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

DLR-BMP4-Rb-96T 96T
EUR 587
  • Should the Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Bone Morphogenetic Protein 4 (BMP4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-b-48Tests 48 Tests
EUR 516

Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-b-96Tests 96 Tests
EUR 716

Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-c-48Tests 48 Tests
EUR 493

Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-c-96Tests 96 Tests
EUR 683

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Ch-48Tests 48 Tests
EUR 470

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Ch-96Tests 96 Tests
EUR 651

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-g-48Tests 48 Tests
EUR 528

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-g-96Tests 96 Tests
EUR 733

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Hu-48Tests 48 Tests
EUR 436

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Hu-96Tests 96 Tests
EUR 601

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Mu-48Tests 48 Tests
EUR 447

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Mu-96Tests 96 Tests
EUR 618

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-p-48Tests 48 Tests
EUR 516

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-p-96Tests 96 Tests
EUR 716

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Ra-48Tests 48 Tests
EUR 470

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Ra-96Tests 96 Tests
EUR 651

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Rb-48Tests 48 Tests
EUR 470

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RDR-BMP4-Rb-96Tests 96 Tests
EUR 651

Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-b-48Tests 48 Tests
EUR 494

Bovine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-b-96Tests 96 Tests
EUR 684

Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-c-48Tests 48 Tests
EUR 472

Canine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-c-96Tests 96 Tests
EUR 653

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Ch-48Tests 48 Tests
EUR 450

Chicken Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Ch-96Tests 96 Tests
EUR 622

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-g-48Tests 48 Tests
EUR 505

Goat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-g-96Tests 96 Tests
EUR 700

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Hu-48Tests 48 Tests
EUR 418

Human Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Hu-96Tests 96 Tests
EUR 575

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Mu-48Tests 48 Tests
EUR 429

Mouse Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Mu-96Tests 96 Tests
EUR 591

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-p-48Tests 48 Tests
EUR 494

Porcine Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-p-96Tests 96 Tests
EUR 684

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Ra-48Tests 48 Tests
EUR 450

Rat Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Ra-96Tests 96 Tests
EUR 622

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Rb-48Tests 48 Tests
EUR 450

Rabbit Bone Morphogenetic Protein 4 (BMP4) ELISA Kit

RD-BMP4-Rb-96Tests 96 Tests
EUR 622

HEK-293T Telomerase Over-Expressing Cell Pellet

abx069991-1Pellet 1 Pellet
EUR 398
  • Shipped within 1-3 working days.

Chymase reagent

30C-CP1129 5 units
EUR 2185
Description: Purified native Human Chymase reagent

Traut's Reagent

2330-1000
EUR 349

Traut's Reagent

2330-500
EUR 207

MTS Reagent

2808-1000
EUR 990

MTS Reagent

2808-250
EUR 365

MTT Reagent

2809-1G
EUR 180

MTT Reagent

2809-5G
EUR 544

BOP reagent

5-02141 25g Ask for price

BOP reagent

5-02142 100g Ask for price

Bluing Reagent

BRT030 30 ml
EUR 60

Bluing Reagent

BRT125 125 ml
EUR 63

Bluing Reagent

BRT3800 1 Gal.
EUR 184

Bluing Reagent

BRT500 500 ml
EUR 76

Bluing Reagent

BRT999 1000 ml
EUR 88

BOP reagent

A7015-100000 100 g
EUR 200
Description: A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.

BOP reagent

A7015-25000 25 g
EUR 113
Description: A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.

Beaucage reagent

HY-100951 10mM/1mL
EUR 126

Bradford reagent

BDE641 100ml
EUR 61.01
  • Product category: Biochemicals/Biology Reagents/Protein Related

BMP4 protein

30R-1255 100 ug
EUR 224
Description: Purified recombinant Human BMP4 protein

BMP4 protein

30R-2651 10 ug
EUR 341
Description: Purified recombinant Human BMP4 protein

BMP4 protein

30R-AB029 5 ug
EUR 273
Description: Purified recombinant Human BMP4 protein

BMP4 antibody

20R-2936 100 ul
EUR 393
Description: Rabbit polyclonal BMP4 antibody

BMP4 antibody

70R-12408 100 ug
EUR 403
Description: Rabbit polyclonal BMP4 antibody

BMP4 antibody

70R-12409 100 ug
EUR 403
Description: Rabbit polyclonal BMP4 antibody

BMP4 antibody

70R-16011 50 ul
EUR 435
Description: Rabbit polyclonal BMP4 antibody

BMP4 Antibody

35652-100ul 100ul
EUR 252

BMP4 antibody

38256-100ul 100ul
EUR 252

BMP4 antibody

10R-2148 100 ul
EUR 403
Description: Mouse monoclonal BMP4 antibody

BMP4 antibody

10R-3460 100 ul
EUR 691
Description: Mouse monoclonal BMP4 antibody

BMP4 antibody

10R-B119a 100 ug
EUR 792
Description: Mouse monoclonal BMP4 antibody

BMP4 antibody

10R-B119B 500 ug
EUR 273
Description: Mouse monoclonal BMP4 antibody

BMP4 Antibody

43852-100ul 100ul
EUR 252

BMP4 Antibody

1-CSB-PA002740GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
  • Form: Liquid
  • Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity Purified
Description: A polyclonal antibody against BMP4. Recognizes BMP4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

BMP4 Antibody

1-CSB-PA05799A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against BMP4. Recognizes BMP4 from Human, Mouse, Rat, Zebrafish. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:1000

BMP4 Antibody

1-CSB-PA763132
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against BMP4. Recognizes BMP4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

BMP4 Antibody

DF6461 200ul
EUR 304
Description: BMP4 Antibody detects endogenous levels of total BMP4.

BMP4 Antibody

1-CSB-PA212919
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against BMP4. Recognizes BMP4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:30-1:150

BMP4 Antibody

AF5175 200ul
EUR 304
Description: BMP4 Antibody detects endogenous levels of total BMP4.

BMP4 Antibody

BF0696 200ul
EUR 376
Description: BMP4 antibody detects endogenous levels of total BMP4.

BMP4 siRNA

20-abx909174
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

BMP4 siRNA

20-abx909175
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

BMP4 Antibody

ABD6461 100 ug
EUR 438

BMP4 Antibody

ABF5175 100 ug
EUR 438

anti-BMP4

LF-PA0093 100 ul
EUR 334
Description: Rabbit polyclonal to BMP4

pENTR223- BMP4

PVT10009 2 ug
EUR 266
Moreover, decreased methylation ranges have been discovered in the promoters of cardiac genes Myh6, Myh7, Myh7b, Tnnc1, Tnni3, Tnnt2, Nppa, Nppb, mef2c, mef2d, Camta2, Cdkn1A, and Cdkn1C. Of these 13 genes, 6 (Myh6, Tnnc1, Tnni3, Tnnt2, Nppa, Nppb) and 1 (Cdkn1C) had elevated or decreased gene expression, respectively. Altogether, these knowledge present that DNMT1 is essential in embryonic cardiomyocytes by regulating DNA methylation, gene expression, gene splicing, and cell perform.

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