Copper deficiency (CuD) is a typical trigger of oxidative cardiac tissue harm in ruminants. The expression of copper chaperone (Cu-Ch) encoding genes permits an in-depth understanding of copper-associated problems, however no earlier research have been undertaken to spotlight Cu-Ch disturbances in coronary heart tissue in ruminants as a result of CuD. The present research aimed to research the Cu-Ch mRNA expression in the coronary heart of goats after experimental CuD and spotlight their relationship with the cardiac measurements.

Eleven male goats had been enrolled in this research and divided into the management group (n = 4) and CuD group (n = 7), which obtained copper-reducing dietary regimes for 7 months. Heart operate was evaluated by electrocardiography and echocardiography, and at the finish of the experiment, all animals had been sacrificed and the cardiac tissues had been collected for histopathology and quantitative mRNA expression by real-time PCR.

In the therapy group, cardiac measurements revealed elevated preload and the existence of cardiac dilatation, and vital cardiac tissue harm by histopathology. Also, the relative mRNA expression of Cu-Ch encoding genes; ATP7A, CTr1, LOX, COX17, in addition to ceruloplasmin (CP), troponin I3 (TNNI3), glutathione peroxidase (GPX1), and matrix metalloprotease inhibitor (MMPI1) genes had been considerably down-regulated in CuD group.

There was a major correlation between investigated genes and a few cardiac operate measurements; in the meantime, a major inverse correlation was noticed between histopathological rating and ATP7B, CTr1, LOX, and COX17. In conclusion, this research revealed that CuD induces cardiac dilatation and alters the mRNA expression of Cu-Ch genes, in addition to TNNI3, GPX1, and MMPI1 which are thought of key components in clinically undetectable CuD-induced cardiac harm in goats which necessitate additional research for feasibility as biomarkers.

Crassulacean acid metabolism (CAM) is a vital photosynthetic pathway for plant adaptation to dry environments. CAM crops characteristic a coordinated interplay between mesophyll and dermis features that includes refined laws of gene expression. Plant microRNAs (miRNAs) are essential post-transcription regulators of gene expression, nonetheless, their roles underlying the CAM pathway stay poorly investigated. Here, we current a research characterizing the expression of miRNAs in an obligate CAM species Kalanchoë marnieriana.

Through sequencing of transcriptome and degradome in mesophyll and epidermal tissues underneath the drought remedies, we recognized differentially expressed miRNAs that had been probably concerned in the regulation of CAM. In whole, we obtained 84 miRNA genes, and eight of them had been decided to be Kalanchoë-specific miRNAs. It is broadly accepted that CAM pathway is regulated by circadian clock.

We confirmed that miR530 was considerably downregulated in epidermal peels underneath drought situations; miR530 focused two tandem zinc knuckle/PLU3 area encoding genes (TZPs) that had been probably concerned in mild signaling and circadian clock pathways. Our work means that the miR530-TZPs module would possibly play a role of regulating CAM-related gene expression in Kalanchoë.

Senescence is the ultimate stage of leaf growth and is important for crops’ health as nutrient relocation from leaves to reproductive organs takes place. Although senescence is vital in nutrient relocation and yield dedication in cereal grain manufacturing, there may be restricted understanding of the genetic and molecular mechanisms that management it in main staple crops equivalent to wheat. Senescence is a extremely orchestrated continuum of interacting pathways all through the lifecycle of a plant. Levels of gene expression, morphogenesis, and phenotypic growth all play key roles.

Yet, most research give attention to a brief window instantly after anthesis. This strategy clearly leaves out key elements controlling the activation, growth, and modulation of the senescence pathway earlier than anthesis, in addition to during the later developmental phases, during which grain growth continues. Here, a computational multiscale modelling strategy integrates multi-omics developmental knowledge to try to simulate senescence at the molecular and plant stage.

To recreate the senescence course of in wheat, core rules had been borrowed from Arabidopsis Thaliana, a extra broadly researched plant mannequin. The resulted mannequin describes temporal gene regulatory networks and their impact on plant morphology resulting in senescence. Digital phenotypes generated from photos utilizing a phenomics platform had been used to seize the dynamics of plant growth.

BFP expression Adenovirus
AVP017	GenTarget	1x109 IFU/ml x 200ul	EUR 418.8
Description: pre-made BFP expression adenovirus, provided in DMEM medium.

Blunt E1 Expression Kit
abx098098-10rxns	Abbexa	10 rxns	EUR 560.4

Blunt E2 Expression Kit
abx098873-10rxns	Abbexa	10 rxns	EUR 560.4

RFP expression Adenovirus, in vivo ready
AVP001-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made RFP expression adenovirus, provided in PBS solution.

CFP expression Adenovirus, in vivo ready
AVP002-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made CFP expression adenovirus, provided in PBS solution.

GFP expression Adenovirus, in vivo ready
AVP011-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made GFP expression adenovirus, provided in PBS solution.

YFP expression Adenovirus, in vivo ready
AVP012-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made YFP expression adenovirus, provided in PBS solution.

BFP expression Adenovirus, in vivo ready
AVP017-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made BFP expression adenovirus, provided in PBS solution.

Rac1 Expression Vector Set
STA-454	Cell Biolabs	1 kit	EUR 1765.2
Description: Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and G12V constitutively active mutant.

RhoA Expression Vector Set
STA-456	Cell Biolabs	1 kit	EUR 1765.2
Description: RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and G14V constitutively active mutant.

Cdc42 Expression Vector Set
STA-455	Cell Biolabs	1 kit	EUR 1765.2
Description: Cdc42 Expression Vector Set contains 3 vectors: Cdc42 wild type, T17N dominant negative mutant, and Q61L constitutively active mutant.

h ADA Expression Lentivirus
LVP923	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: ADA, containing a RFP-Blasticidin dual selection marker.

h IL6 Expression Lentivirus
LVP1144	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h CD4 Expression Lentivirus
LVP1152	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CD4, containing a RFP-Blasticidin dual selection marker.

h IL4 Expression Lentivirus
LVP1161	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: IL4, containing a RFP-Blasticidin dual selection marker.

h IL7 Expression Lentivirus
LVP1162	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker.

h KDR Expression Lentivirus
LVP1176	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: KDR, containing a RFP-Blasticidin dual selection marker.

h FAS Expression Lentivirus
LVP1181	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: FAS, containing a RFP-Blasticidin dual selection marker.

pAAV-MCS Expression Vector
VPK-410	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

h OCT4 expression Adenovirus, in vivo ready
AVP013-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in PBS solution for in vivo application.

h SOX2 expression Adenovirus, in vivo ready
AVP014-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in PBS solution for in vivo application.

h OCT4 expression Adenovirus
AVP013	GenTarget	1x109 IFU/ml x 200ul	EUR 418.8
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in DMEM medium.

h SOX2 expression Adenovirus
AVP014	GenTarget	1x109 IFU/ml x 50ul	EUR 418.8
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in DMEM medium.

h CDR1 Expression Lentivirus
LVP917	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CDR1, containing a RFP-Blasticidin dual selection marker.

h CD47 Expression Lentivirus
LVP918	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CD47, containing a RFP-Blasticidin dual selection marker.

h ESR1 Expression Lentivirus
LVP924	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: ESR1, containing a RFP-Blasticidin dual selection marker.

r Syn1 Expression Lentivirus
LVP925	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for rat target: Syn1, containing a RFP-Blasticidin dual selection marker.

h NME4 Expression Lentivirus
LVP932	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NME4, containing a RFP-Blasticidin dual selection marker.

h EGFR Expression Lentivirus
LVP1142	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: EGFR, containing a RFP-Blasticidin dual selection marker.

h NRP1 Expression Lentivirus
LVP1145	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h MUC1 Expression Lentivirus
LVP1148	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h CD8a Expression Lentivirus
LVP1151	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CD8a, containing a RFP-Blasticidin dual selection marker.

h PIGF Expression Lentivirus
LVP1154	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: PIGF, containing a RFP-Blasticidin dual selection marker.

h BRAF Expression Lentivirus
LVP1156	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: BRAF, containing a RFP-Blasticidin dual selection marker.

h ROS1 Expression Lentivirus
LVP1158	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: ROS1, containing a RFP-Blasticidin dual selection marker.

h CD3E Expression Lentivirus
LVP1163	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker.

h KLK3 Expression Lentivirus
LVP1171	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: KLK3, containing a RFP-Blasticidin dual selection marker.

h NEK6 Expression Lentivirus
LVP1182	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NEK6, containing a RFP-Blasticidin dual selection marker.

h NEK7 Expression Lentivirus
LVP1183	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NEK7, containing a RFP-Blasticidin dual selection marker.

h LIN28 expression Adenovirus, in vivo ready
AVP015-PBS	GenTarget	1x1011 IFU/ml x 50ul	EUR 852
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in PBS solution for in vivo application.

h LIN28 expression Adenovirus
AVP015	GenTarget	1x109 IFU/ml x 200ul	EUR 418.8
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in DMEM medium.

h GPNMB Expression Lentivirus
LVP921	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: GPNMB, containing a RFP-Blasticidin dual selection marker.

h DECR1 Expression Lentivirus
LVP927	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: DECR1, containing a RFP-Blasticidin dual selection marker.

h DECR2 Expression Lentivirus
LVP928	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: DECR2, containing a RFP-Blasticidin dual selection marker.

h NMRK1 Expression Lentivirus
LVP930	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NMRK1, containing a RFP-Blasticidin dual selection marker.

h PITX3 Expression Lentivirus
LVP931	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: PITX3, containing a RFP-Blasticidin dual selection marker.

h HDAC1 Expression Lentivirus
LVP1143	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h VEGFB Expression Lentivirus
LVP1146	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h PARP1 Expression Lentivirus
LVP1149	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h IL3RA Expression Lentivirus
LVP1150	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: IL3RA, containing a RFP-Blasticidin dual selection marker.

h PTCH1 Expression Lentivirus
LVP1155	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: PTCH1, containing a RFP-Blasticidin dual selection marker.

h SART3 Expression Lentivirus
LVP1159	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: SART3, containing a RFP-Blasticidin dual selection marker.

h TIGIT Expression Lentivirus
LVP1160	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: TIGIT, containing a RFP-Blasticidin dual selection marker.

h EDNRA Expression Lentivirus
LVP1165	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: EDNRA containing a RFP-Blasticidin dual selection marker.

h Foxp3 Expression Lentivirus
LVP1172	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: Foxp3, containing a RFP-Blasticidin dual selection marker.

m RIKEN Expression Lentivirus
LVP1174	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for mouse target: RIKEN, containing a RFP-Blasticidin dual selection marker.

h APLP2 Expression Lentivirus
LVP1177	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: APLP2, containing a RFP-Blasticidin dual selection marker.

h PCSK9 Expression Lentivirus
LVP1178	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: PCSK9, containing a RFP-Blasticidin dual selection marker.

h NTSR1 Expression Lentivirus
LVP1179	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NTSR1, containing a RFP-Blasticidin dual selection marker.

pscAAV-MCS Expression Vector
VPK-430	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

m CTAGA1 Expression Lentivirus
LVP916	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for mouse target: CTAGA1, containing a RFP-Blasticidin dual selection marker.

h SKIV2L Expression Lentivirus
LVP919	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: SKIV2L, containing a RFP-Blasticidin dual selection marker.

h SKIV2L Expression Lentivirus
LVP919-GP	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: SKIV2L, containing a GFP-Puromycin dual selection marker.

h TP5313 Expression Lentivirus
LVP926	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: TP5313, containing a RFP-Blasticidin dual selection marker.

h ELOVL5 Expression Lentivirus
LVP929	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: ELOVL5, containing a RFP-Blasticidin dual selection marker.

h MAGEA3 Expression Lentivirus
LVP1147	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h NANOS3 Expression Lentivirus
LVP1164	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NANOS3, containing a RFP-Blasticidin dual selection marker.

h IL1RL1 Expression Lentivirus
LVP1168	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: IL1RL1, containing a RFP-Blasticidin dual selection marker.

h CTAG1B Expression Lentivirus
LVP1169	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CTAG1B, containing a RFP-Blasticidin dual selection marker.

h MAGEA3 Expression Lentivirus
LVP1170	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: MAGEA3, containing a RFP-Blasticidin dual selection marker.

h COX7A1 Expression Lentivirus
LVP1173	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: COX7A1, containing a RFP-Blasticidin dual selection marker.

h BCL11B Expression Lentivirus
LVP1180	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: BCL11B, containing a RFP-Blasticidin dual selection marker.

pUC57-sgRNA expression vector
PVT18003	Lifescience Market	2 ug	EUR 309.6

H-Ras Expression Vector Set
STA-457	Cell Biolabs	1 kit	EUR 1765.2
Description: H-Ras Expression Vector Set contains 3 vectors: H-Ras wild type, T19N dominant negative mutant, and G12V constitutively active mutant.

ANPRA/Aequorin Expression vector
60641	BPS Bioscience	20 µg	EUR 900
Description: The ANPRA/Aequorin expression vector is designed to co-express human atrial natriuretic peptide receptor A (ANPRA, also called natriuretic peptide receptor A/guanylate cyclase A) and jellyfish (Aequorea victoria) Aequorin in mammalian cells.

h CEACAM5 Expression Lentivirus
LVP1153	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CEACAM5, containing a RFP-Blasticidin dual selection marker.

h TNFSF11 Expression Lentivirus
LVP1157	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: TNFSF11, containing a RFP-Blasticidin dual selection marker.

BRAF, His-Tag (High Expression)
41237	BPS Bioscience	10 µg	EUR 375
Description: Human BRAF, also known as B-RAF1 and RAFB1, with 18 mutations to improve expression; S446A, S447A, I543A, I544S, I551K, Q562R, L588N, K630S, F667E, Y672S, A688R, L706S, Q709R, S713E, L716E, S720E, P722S, K723G. GenBank Accession #NM_004333, a.a. 444-723 with N-terminal His-tag, expressed in E. coli cells. MW = 33 kDa.

h TNFRSF1B Expression Lentivirus
LVP922	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: TNFRSF1B, containing a RFP-Blasticidin dual selection marker.

h KIAA1324 Expression Lentivirus
LVP1175	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: KIAA1324, containing a RFP-Blasticidin dual selection marker.

h KIAA0319L Expression Lentivirus
LVP920	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for human target: KIAA0319L, containing a RFP-Blasticidin dual selection marker.

GFP-Rac1 Expression Vector Set
STA-450	Cell Biolabs	1 kit	EUR 1939.2
Description: GFP-Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence.

GFP-RhoA Expression Vector Set
STA-452	Cell Biolabs	1 kit	EUR 1939.2
Description: GFP-RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and Q63L constitutively active mutant. Each vector also contains a GFP reporter sequence.

PhiC31 Integrase Expression Plasmid
FC200PA-1	SBI	10ug	EUR 496

GFP-Cdc42 Expression Vector Set
STA-451	Cell Biolabs	1 kit	EUR 1939.2
Description: GFP-Cdc42 Expression Vector Set contains 3 vectors: Cdc42 wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence.

Active Rac1 Expression Vector Set
STA-458	Cell Biolabs	1 kit	EUR 1765.2
Description: Active Rac1 Expression Vector Set contains 3 vectors expressing different constitutively active mutants of Rac1: Q61L, Q61L/F37A, and Q61L/Y40C.

pCMV-GFP-LC3 Expression Vector
CBA-401	Cell Biolabs	100 µL	EUR 1243.2
Description: Expression vector contains a fusion of GFP and LC3. A separate GFP control vector is also included.

h KRAS (G12D) Expression Lentivirus
LVP1166	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for a mutant (G12D) of human target: KRAS containing a RFP-Blasticidin dual selection marker.

Tet-on circRNA Expression Vector
PVT14643	Lifescience Market	2 ug	EUR 843.6

PinPoint Integrase Expression Plasmid
PIN200A-1	SBI	10ug	EUR 688

h TP53 (R175H) Expression Lentivirus
LVP1167	GenTarget	1x107 IFU/ml x 200ul	EUR 541.2
Description: Pre-made over-expression lentivirus for a mutant R175H) of human target: TP53, containing a RFP-Blasticidin dual selection marker.

pAAV-IRES-Neo Expression Vector
VPK-416	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

pAAV-IRES-GFP Expression Vector
VPK-418	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

pAAV-IRES-Bsd Expression Vector
VPK-419	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

pAAV-IRES-Puro Expression Vector
VPK-415	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

pAAV-IRES-Hygro Expression Vector
VPK-417	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

CEACAM5 CHO Cell Line (Low Expression)
78704-L	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.

Active H-Ras Expression Vector Set
STA-459	Cell Biolabs	1 kit	EUR 1765.2
Description: Active H-Ras Expression Vector Set contains 3 vectors expressing different constitutively active mutants of H-Ras: V12, V12S35, and V12C40.

CD36 HEK293 Cell Line (High Expression)
78526-H	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line.

CEACAM5 CHO Cell Line (High Expression)
78704-H	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.

AAV-1 Helper Free Expression System
VPK-410-SER1	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-2 Helper Free Expression System
VPK-410-SER2	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-3 Helper Free Expression System
VPK-410-SER3	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-4 Helper Free Expression System
VPK-410-SER4	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-5 Helper Free Expression System
VPK-410-SER5	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-6 Helper Free Expression System
VPK-410-SER6	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

Gryphon Retroviral Expression System I
ABP-RVK-10001	Allele Biotech	1 set	Ask for price
Description: PRODUCT LINE DISCONTINUED. Please contact us.

Gryphon Retroviral Expression System II
ABP-RVK-10002	Allele Biotech	1 set	Ask for price
Description: PRODUCT LINE DISCONTINUED. Please contact us.

B7-H3 CHO Cell Line (Low Expression)
78541-L	BPS Bioscience	2 vials	EUR 7150
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

AAV-DJ Helper Free Expression System
VPK-410-DJ	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

B7-H3 CHO Cell Line (High Expression)
78541-H	BPS Bioscience	2 vials	EUR 7150
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

EP Reagent Biuret Reagent
1011601	Scientific Laboratory Supplies	1L	EUR 52.8

pRedPuro shRNA expression lentivector (EF1)
SI516A-1	SBI	10 ug	EUR 594

pAAV-MCS Promoterless Expression Vector
VPK-411	Cell Biolabs	10 µg	EUR 776.4
Description: Clone your gene of interest into this AAV Expression Vector, then co-transfect along with AAV packaging vectors into a packaging host cell line such as 293AAV.

pSMPUW-Neo Lentiviral Expression Vector
VPK-213	Cell Biolabs	10 µg	EUR 748.8
Description: Clone your gene of interest into this Lentiviral Expression Vector, then co-transfect along with lentiviral packaging vectors into a packaging cell line such as 293LTV. This expression vector is compatible with any 2nd or 3rd generation lentiviral packaging system, but due to its design it is best matched with our ViraSafe packaging vectors to produce the highest viral titer.

CD36 HEK293 Cell Line (Medium Expression)
78526-M	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal HEK293 cell line stably expressing full length human CD36. The stable clonal cell line was selected for medium and high levels of CD36 expression compared to the parental HEK293 cell line.

CEACAM5 CHO Cell Line (Medium Expression)
78704-M	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.

Human Myelin expression factor 2 (MYEF2)
1-CSB-EP015283HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Myelin expression factor 2(MYEF2),partial expressed in E.coli

scAAV-1 Helper Free Expression System
VPK-430-SER1	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-2 Helper Free Expression System
VPK-430-SER2	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-3 Helper Free Expression System
VPK-430-SER3	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-4 Helper Free Expression System
VPK-430-SER4	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-5 Helper Free Expression System
VPK-430-SER5	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

scAAV-6 Helper Free Expression System
VPK-430-SER6	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

pSMPUW-Puro Lentiviral Expression Vector
VPK-212	Cell Biolabs	10 µg	EUR 748.8
Description: Clone your gene of interest into this Lentiviral Expression Vector, then co-transfect along with lentiviral packaging vectors into a packaging cell line such as 293LTV. This expression vector is compatible with any 2nd or 3rd generation lentiviral packaging system, but due to its design it is best matched with our ViraSafe packaging vectors to produce the highest viral titer.

Protein Limb Expression 1 (LIX1) Antibody
20-abx318393	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Protein Limb Expression 1 (LIX1) Antibody
abx146234-100ug	Abbexa	100 ug	EUR 469.2

Protein Limb Expression 1 (LIX1) Antibody
abx025913-400ul	Abbexa	400 ul	EUR 627.6

Protein Limb Expression 1 (LIX1) Antibody
abx025913-80l	Abbexa	80 µl	EUR 343.2

scAAV-DJ Helper Free Expression System
VPK-430-DJ	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2.

B7-H3 CHO Cell Line (Medium Expression)
78541-M	BPS Bioscience	2 vials	EUR 7150
Description: B7 homolog 3 protein (B7-H3) CHO Cell line is a recombinant clonal stable CHO cell line expressing full length human B7-H3 protein, also known as cluster of differentiation 276 (CD276, B7H3; B7RP-2; 4Ig-B7-H3). Surface expression of B7-H3 was confirmed by flow cytometry. Each stable clonal cell line was selected for High, Medium, or Low levels of B7-H3 expression to mimic different B7-H3 expression levels in various cancer types.

Expression Negative Control Lentivirus (G418)
79902-G	BPS Bioscience	500 µl x 2	EUR 795
Description: The Expression Negative Control Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The controls package the same virus particles as the target expression virus, but they do not express a specific protein under the CMV promoter. _x000D_The Expression Negative Control Lentivirus (G418) expresses the gene for aminoglycoside 3' phosphotransferase, which confers resistance to kanamycin, neomycin, and geneticin (G418)._x000D_The Expression Negative Control Lentivirus (Hygromycin) expresses the gene for hygromycin B phosphotransferase, which confers resistance to Hygromycin._x000D_The Expression Negative Control Lentivirus (Puromycin) expresses the gene for puromycin N-acetyl-transferase, which confers resistance to puromycin._x000D_ _x000D_

pGreenPuro shRNA expression lentivector (CMV)
SI505A-1	SBI	10 ug	EUR 594

pGreenPuro shRNA expression lentivector (EF1)
SI506A-1	SBI	10 ug	EUR 594

pSMPUW-Hygro Lentiviral Expression Vector
VPK-214	Cell Biolabs	10 µg	EUR 748.8
Description: Clone your gene of interest into this Lentiviral Expression Vector, then co-transfect along with lentiviral packaging vectors into a packaging cell line such as 293LTV. This expression vector is compatible with any 2nd or 3rd generation lentiviral packaging system, but due to its design it is best matched with our ViraSafe packaging vectors to produce the highest viral titer.

RAPAd® RSV Adenoviral Expression System
VPK-251	Cell Biolabs	1 kit	EUR 1243.2
Description: Making an adenovirus with traditional recombinant methods takes 2-3 months and requires tedious plaque recombination. More recent technologies have shortened this time somewhat, but still produce relatively high amounts of wild type (replication-competent) plaques, levels of which increase with serial amplification. The RAPAd® Adenoviral Expression Systems produce recombinant adenovirus with substantially reduced wild-type virus, while considerably shortening the production time to 2-3 weeks. Serial amplification of adenovirus produced using the RAPAd® system does not significantly increase replication-competent adenovirus levels. The system uses a backbone vector from which the 5' ITR, packaging signal and E1 sequences have been removed.

RAPAd® CMV Adenoviral Expression System
VPK-252	Cell Biolabs	1 kit	EUR 1243.2
Description: Making an adenovirus with traditional recombinant methods takes 2-3 months and requires tedious plaque recombination. More recent technologies have shortened this time somewhat, but still produce relatively high amounts of wild type (replication-competent) plaques, levels of which increase with serial amplification. The RAPAd® Adenoviral Expression Systems produce recombinant adenovirus with substantially reduced wild-type virus, while considerably shortening the production time to 2-3 weeks. Serial amplification of adenovirus produced using the RAPAd® system does not significantly increase replication-competent adenovirus levels. The system uses a backbone vector from which the 5' ITR, packaging signal and E1 sequences have been removed.

Claudin-6 CHO Cell Line (Low Expression)
78527-L	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal CHO cell line stably expressing full-length human claudin-6 (CLDN6 gene accession number NM_021195.5).  Surface expression of claudin 6 was confirmed by flow cytometry. The stable clonal cell line was selected for high, medium, or low levels of claudin-6 expression compared to the parental CHO-K1 cell line.

Myelin Expression Factor 2 (MYEF2) Antibody
abx235464-100ug	Abbexa	100 ug	EUR 577.2

Myelin Expression Factor 2 (MYEF2) Antibody
20-abx109333	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Myelin Expression Factor 2 (MYEF2) Antibody
20-abx113906	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

EP Reagent Iodoplatinate Reagent
1046300	Scientific Laboratory Supplies	200ML	EUR 446.4

Claudin-6 CHO Cell Line (High Expression)
78527-H	BPS Bioscience	2 vials	EUR 7150
Description: Recombinant clonal CHO cell line stably expressing full-length human claudin-6 (CLDN6 gene accession number NM_021195.5).  Surface expression of claudin 6 was confirmed by flow cytometry. The stable clonal cell line was selected for high, medium, or low levels of claudin-6 expression compared to the parental CHO-K1 cell line.

AAV-DJ/8 Helper Free Expression System
VPK-410-DJ-8	Cell Biolabs	1 kit	EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

This work offers the foundation for the utility of computational modelling to advance understanding of the advanced organic trait senescence. This helps the growth of a predictive framework enabling its prediction in altering or excessive environmental situations, with a view to focused choice for optimum lifecycle period for bettering resilience to local weather change.